Literature summary extracted from
Ferguson, K.L.; Eschweiler, J.D.; Ruotolo, B.T.; Marsh, E.N.G.
Evidence for a 1,3-dipolar cyclo-addition mechanism in the decarboxylation of phenylacrylic acids catalyzed by ferulic acid decarboxylase (2017), J. Am. Chem. Soc., 139, 10972-10975 .
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
4.1.1.102 |
(Z)-2-fluoro-2-nitro-vinylbenzene |
potent irreversible inhibitor. At 0.05 mM, enzyme is inactive within 10 min |
Saccharomyces cerevisiae |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
4.1.1.102 |
Saccharomyces cerevisiae |
Q03034 |
- |
- |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
4.1.1.102 |
additional information |
proposed mechanism involves the formation of a putative pentacyclic intermediate formed by a 1,3 dipolar cyclo-addition of cofactor prenylated FMN with the alpha-beta double bond of the substrate, which serves to activate the substrate toward decarboxylation. Prenylated FMN is able to function as a dipole in a 1,3 dipolar cyclo-addition reaction as the initial step |
Saccharomyces cerevisiae |
? |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
4.1.1.102 |
FDC1 |
- |
Saccharomyces cerevisiae |
Cofactor
EC Number |
Cofactor |
Comment |
Organism |
Structure |
---|
4.1.1.102 |
FMN |
cofactor is prenylated FMN |
Saccharomyces cerevisiae |
|